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Objective To assess the application of 186110-restriction fragment length polymorphism (RFLP), Spoligotyping and mycobacterial interspersed repetitive unit(MIRU) in the epidemiology of tuberculosis, and to discuss the characteristic of the Mycobacterium tuberculosis strains in different regions in China.

目的 评价IS6110-限制型片段长度多态性(IS6110-RFLP)、间隔区寡核甘酸分型(spoligotyping)及分枝杆菌散在重复单位(MIRU)三种分型方法在结核病流行病学上的应用，探讨我国不同地区结核分枝杆菌菌株的基因型特点。