internal enol ether

A side product in preparation of clarithromycin was isolated and its structure was elucidated by UV,IR,NMR and MS spectra as the internal enol ether of erythromycin.

在以红霉素A为原料制备克拉霉素时,将一个副产物纯化至HPLC检测纯度在98%以上,通过理化性质测定,确证其结构为红霉素烯醇醚。

Using the proper silyl enol ethers and tert - butyl chloride agent with CH2Cl2 as an eluent,a - tert - butylated carbonyl compounds were conveniently prepared by column chromatography on zinc chloride coated microporous spherical silica gel in good yields.

在担载氯化锌的微孔球状硅胶色谱柱上,用溶有适宜配比的硅基烯醇醚/叔丁基氯的二氯甲烷溶液作流动相,再经二氯甲烷洗脱,水解等步骤处理后,可制得高收率的α-叔丁基醛酮化合物。