guanase

O 6-methylguanine-DNA methyltransferase (MGMT) is a specific DNA repair protein that exist in cells and tissues from bacteria to mammalias.

甲基鸟嘌呤甲基转移酶 (O6 methylguanine DNAmethyltransferase,MGMT)是从细菌到哺乳类机体中存在的一种独特的DNA修复蛋白 ,其作用是在DNA损伤的修复过程 ,催化DNA分子鸟嘌呤O6位上的烷基从鸟嘌呤碱基转移至MGMT蛋白的半胱氨酸残基上 ,而使DNA分子鸟嘌呤复原 。

Objective To investigate the sensitivity to Adriamycin of down-regulated cells expressed hOGG1 gene which target to oxidative DNA damage and repair,and provide more experimental evidence of sensitizing the response of tumor to chemotherapy.

目的研究8-羟基鸟嘌呤DNA糖苷酶1基因(hOGG 1)低表达细胞对阿霉素的敏感性,为化疗增敏提供实验依据。